Afzelin can be described as a glycosyloxyflavone. There are many chemical stores from where you can buy chemicals. You can visit the most trusted ones and can order your required one for research and for other purpose. Buy chemicals online and afzelin from different vendors.
MeSH Entry Terms
- Molecular Formula C21H20O10
- Average mass 378 Da
- Monoisotopic mass 105652 Da
|Property Name||Property Value||Reference|
|Molecular Weight||432.4||Computed by PubChem 2.1 (PubChem release 2021.05.07)|
|XLogP3-AA||1.2||Computed by XLogP3 3.0 (PubChem release 2021.05.07)|
|Hydrogen Bond Donor Count||6||Computed by Cactvs 126.96.36.199 (PubChem release 2021.05.07)|
|Hydrogen Bond Acceptor Count||10||Computed by Cactvs 188.8.131.52 (PubChem release 2021.05.07)|
|Rotatable Bond Count||3||Computed by Cactvs 184.108.40.206 (PubChem release 2021.05.07)|
|Exact Mass||432.10564683||Computed by PubChem 2.1 (PubChem release 2021.05.07)|
|Monoisotopic Mass||432.10564683||Computed by PubChem 2.1 (PubChem release 2021.05.07)|
|Topological Polar Surface Area||166 Å²||Computed by Cactvs 220.127.116.11 (PubChem release 2021.05.07)|
|Heavy Atom Count||31||Computed by PubChem|
|Formal Charge||0||Computed by PubChem|
|Complexity||702||Computed by Cactvs 18.104.22.168 (PubChem release 2021.05.07)|
|Isotope Atom Count||0||Computed by PubChem|
|Defined Atom Stereocenter Count||5||Computed by PubChem|
|Undefined Atom Stereocenter Count||0||Computed by PubChem|
|Defined Bond Stereocenter Count||0||Computed by PubChem|
|Undefined Bond Stereocenter Count||0||Computed by PubChem|
|Covalently-Bonded Unit Count||1||Computed by PubChem|
|Compound Is Canonicalized||Yes||Computed by PubChem (release 2021.05.07)|
Afzelin General description
Afzelin is a natural product made from plant material. Nymphaea or atom is the primary source.
Afzelin has antibacterial, DNA-protective, and antioxidant properties. It can be detected in HPLC (high-performance liquid chromatography) analysis Comarum PalustreL. Extract.
Antibacterial, DNA-protective, and antioxidant.
Afzelin has been shown to have antibacterial, anti-inflammatory, and anti-tumor activity. Therefore, Afzelin could be used to treat P.aeruginosa-related disorders. Afzelin can also be used to promote apoptosis and inhibit breast cancer cell proliferation. In addition, it has anti-asthmatic activity in a mouse model.
Afzelin, kaempferol 3O-rhamnoside and kaempferol 3O-rhamnoside both belong to the flavonol sugar group. It can be found in 56 plants. It has been found in 56 plants, making it easily accessible.
GalN/LPS treated mice with Afzelin had a greater survival rate and lower serum levels of pro-inflammatory and cytokines. Afzelin decreased mitochondrial swelling in GalN/LPS mice and increased mitochondrial glutamate dehydrogenase activity. Afzelin promoted mitochondrial biogenesis. This was evident by increased PPAR-g activator 1a, nuclear Respir factor 1, and mitochondrial transcript factor A. It is also reduced the levels of mitophagy related proteins, parkin, and PTEN-induced kinase 1. GalN/LPS increased the levels of dynamin-related protein one and dynamin-related prot1, respectively, but these effects were reduced by afzelin.
This chemical is a natural flavonol glycoside flavonol product that’s derived from Kaempferol. It contains four hydroxy group positions 3, 5, 7, and 4 on the flavone. This chemical is created by forming a glycosidic bond between the 3-O-atom of Kaempferol and a-L–rhamnose. This results in the presence of 3 phenol and five stereogenic centers. It was recently evaluated for its biological properties. It has been shown to have antibacterial activity and high aldose reductase inhibitory activities.
These effects of afzelin might be related to restored cholinergic dysfunction, enhanced LTP, and an increase of BDNF/CREB signaling.
Our findings showed that afzelin protects liver injury from GalN/LPS by stimulating mitochondrial biogenesis, suppressing excess mitophagy, and balancing the mitochondrial dynamics.