The recommended LD50 of the caffeine found in rats is 192 mg/kg. MSDS: An acute fatal caffeine overdose for humans is around 10- 14 grams (equivalent to 150-200 mg/kg of the body’s weight). Overdose of caffeine: If there is a caffeine overdose, seizures can occur due to caffeine being an agonist of the central nervous system. It is recommended to use it with extreme caution for those suffering from seizures, epilepsy, or other disorders. The symptoms of an overdose could include nausea, vomiting, diarrhea, and stomach upset.
Intoxication from caffeine molecule is listed within the WHO’s International Classification of Diseases (ICD-10). Arousal, anxiety, insomnia, tremors, tachycardia, psychomotor agitation, tachycardia and in some instances, deaths can occur depending on the quantity the caffeine intake. Overdose is more likely to be experienced by those who don’t consume regular amounts of caffeine but drink energy drinks.
Hemodialysis and activated charcoal can help prevent the recurrence of an overdose. However, they also hinder metabolism and absorption. Benzodiazepine drugs are used to treat or prevent seizures. Vasopressors and IV fluids can be required to treat the effects of caffeine on blood pressure. Additionally, beta-blocking medications are an excellent option to treat arrhythmias that could be present, including defibrillation and Resuscitation when the arrhythmias become dangerous. You can research chemicals online.
Initial reports of liver damage due to SLIMQUICK were reported in 2012 and followed by stories in 2014. in 2016, all of which came from all of the United States. More than two dozen instances attributed to the SLIMQUICK product have been documented in the research literature. The publications discussed acute hepatocellular damage that occurred within 3 to 12 weeks after introducing the use of a SLIMQUICK product that contained extracts of green tea and caffeine and a variety of herbal extracts.
A certain amount of caffeine molecule consumption is commonplace in modern society. It is estimated that 90 percent of adults in the United States consume caffeine daily, with an average of 200 mg per day. But despite the widespread usage, there isn’t any evidence to suggest that the regular consumption of coffee or caffeine causes harm to the liver. Studies on epidemiology indicate that coffee consumption could have modest benefits against the progression of chronic liver diseases and the growth of liver cancer. In highly toxic doses, caffeine may damage muscles, the heart and brain function, but it is not connected to any clinically visible liver damage.
It is also unclear whether the hepatic-related symptoms resulted from caffeine as a whole or other components that are commonly found in energy drinks like herbs, vitamins or other products made of botanicals. In the reports of caffeine-related overdoses, and autopsies in particular liver damage, the word “hepatic” is not discussed. Therefore, caffeine is not likely to cause liver injury; however, the many high caffeine energy drinks commonly consumed could cause liver damage when consumed in overdose.
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Caffeine is suggested as a short-term treatment of prematurity-related apnea in infants. It is also used off-label to treat and prevent bronchopulmonary dysplasia that is caused by premature birth. Additionally, it is recommended in conjunction with sodium benzoate for the treatment of respiratory depression that is caused by an overdose of CNS depressants. Caffeine is a variety of uses available over the counter and can be present in products for energy, athletic enhancement products, pain relief items and cosmetics.
Chemical and physical properties
|Property Name||Property Value||Reference|
|Molecular Weight||194.19||Computed by PubChem 2.1 (PubChem release 2021.05.07)|
|XLogP3||-0.1||Computed by XLogP3 3.0 (PubChem release 2021.05.07)|
|Hydrogen Bond Donor Count||0||Computed by Cactvs 126.96.36.199 (PubChem release 2021.05.07)|
|Hydrogen Bond Acceptor Count||3||Computed by Cactvs 188.8.131.52 (PubChem release 2021.05.07)|
|Rotatable Bond Count||0||Computed by Cactvs 184.108.40.206 (PubChem release 2021.05.07)|
|Exact Mass||194.08037557||Computed by PubChem 2.1 (PubChem release 2021.05.07)|
|Monoisotopic Mass||194.08037557||Computed by PubChem 2.1 (PubChem release 2021.05.07)|
|Topological Polar Surface Area||58.4 Å²||Computed by Cactvs 220.127.116.11 (PubChem release 2021.05.07)|
|Heavy Atom Count||14||Computed by PubChem|
|Formal Charge||0||Computed by PubChem|
|Complexity||293||Computed by Cactvs 18.104.22.168 (PubChem release 2021.05.07)|
|Isotope Atom Count||0||Computed by PubChem|